Thiol redox control via thioredoxin and glutaredoxin systems

被引：341

作者：

Holmgren, A ^{[1
]}

Johansson, C ^{[1
]}

Berndt, C ^{[1
]}

Lönn, ME ^{[1
]}

Hudemann, C ^{[1
]}

Lillig, CH ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Med Nobel Inst Biochem, SE-17177 Stockholm, Sweden

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

disulphide; glutaredoxin (Grx); GSH; thiol redox control; thioredoxin (Trx); thioredoxin reductase (TrxR);

D O I：

10.1042/BST0331375

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.

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页码：1375 / 1377

页数：3

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