OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease

被引：60

作者：

Li, Mei ^{[1
]}

Gao, Xiang ^{[1
]}

Guo, Chang-Cun ^{[2
]}

Wu, Kai-Chun ^{[2
]}

Zhang, Xin ^{[2
]}

Hu, Pin-Jin ^{[1
]}

机构：

[1] Zhongshan Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510089, Guangdong, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Gastroenterol, Xian 710032, Shaanxi Prov, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 31期

关键词：

inflammatory bowel disease; ulcerative colitis; Crohn's disease; CARD15; carnitine/organic cation transporter gene;

D O I：

10.3748/wjg.14.4923

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD). METHODS: A total of 61 patients with Crohn's disease (CD), 151 patients with ulcerative colitis (UC), and 200 unrelated healthy controls were genotyped. Genotyping was performed by sequence specific primer polymerase chain reaction (PCR-SSP) or by restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: Among the subjects in our study groups, including patients with CD, UC and healthy controls, none had OCTN and CARD15 variants and very rare IBD family history was found in our patients with the percentage of 0 (0/61 with CD) and 1.3% (2/151 with UC). CONCLUSION: Our results indicate that although OCTN or CARD15 variation is associated with susceptibility to IBD in Western populations, these might be rare and may not be associated with susceptibility to IBD in Chinese patients. (c) 2008 The WJG Press. All rights reserved.

引用

页码：4923 / 4927

页数：5

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