Immunocyte Ca2+ influx system mediated by LTRPC2

被引：376

作者：

Sano, Y ^{[1
]}

Inamura, K ^{[1
]}

Miyake, A ^{[1
]}

Mochizuki, S ^{[1
]}

Yokoi, H ^{[1
]}

Matsushime, H ^{[1
]}

Furuichi, K ^{[1
]}

机构：

[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Mol Med Labs, Tsukuba, Ibaraki 3058585, Japan

来源：

SCIENCE | 2001年 / 293卷 / 5533期

关键词：

D O I：

10.1126/science.1062473

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Call influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5'-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.

引用

页码：1327 / 1330

页数：4

共 25 条

[1] Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo [J].