The effects of restraint stress on the neuropathogenesis of Theiler's virus infection: I. Acute disease

被引:51
作者
Campbell, T [1 ]
Meagher, MW
Sieve, A
Scott, B
Storts, R
Welsh, TH
Welsh, CJR
机构
[1] Texas A&M Univ, Coll Vet Med, Dept Vet Anat & Publ Hlth, College Stn, TX 77843 USA
[2] Texas A&M Univ, Coll Vet Med, Dept Vet Pathobiol, College Stn, TX 77843 USA
[3] Texas A&M Univ, Coll Liberal Arts, Dept Psychol, College Stn, TX 77843 USA
[4] Texas A&M Univ, Coll Agr, Dept Anim Sci, College Stn, TX 77843 USA
关键词
Theiler's virus; restraint stress; glucocorticoids; immunosuppression; neurotropic virus;
D O I
10.1006/brbi.2000.0598
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Restraint stress was found to have a profound effect on the acute phase of Theiler's virus infection. Increased mortality rates were observed in restrained CBA mice infected with the BeAn strain of Theiler's virus. In addition, restrained mice developed higher CNS viral titers than infected/nonrestrained mice. Thymic atrophy was observed in both infected and uninfected restrained mice. Decreased microgliosis, perivascular cuffing, and astrocytosis were observed in restrained mice compared to nonrestrained infected mice at 7 days postinfection. Restraint-stressed mice also developed decreased numbers of lymphocytes and increased numbers of neutrophils in the blood. The mechanism proposed for these alterations involves stress-induced corticosterone, which causes immunosuppression, decreased trafficking of inflammatory cells in the CNS, and, consequently, increased viral replication. (C) 2001 Academic Press.
引用
收藏
页码:235 / 254
页数:20
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