Alzheimer's disease: Clues from flies and worms

被引：38

作者：

Anderton, BH ^{[1
]}

机构：

[1] Univ London Kings Coll, Inst Psychiat, Dept Neurosci, London SE5 8AF, England

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(99)80062-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Presenilin mutations give rise to familial Alzheimer's disease and result in elevated production of amyloid beta peptide. Recent evidence that presenilins act in developmental signalling pathways may be the key to understanding how senile plaques, neurofibrillary tangles and apoptosis are all biochemically linked.

引用

页码：R106 / R109

页数：4

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