Cell-intrinsic regulators of proliferation in vertebrate retinal progenitors

被引：56

作者：

Levine, EM

Green, ES

机构：

[1] Univ Utah, Eccles Inst Human Genet, Dept Ophthalmol, Salt Lake City, UT 84112 USA

[2] Univ Utah, Eccles Inst Human Genet, Dept Visual Sci, Salt Lake City, UT 84112 USA

[3] Univ Utah, Eccles Inst Human Genet, Dept Neurobiol, Salt Lake City, UT 84112 USA

[4] Univ Utah, Eccles Inst Human Genet, Dept Anat, Salt Lake City, UT 84112 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 01期

关键词：

Chx10; Six6; Rx; cyclin D1; p27Kip1;

D O I：

10.1016/j.semcdb.2003.09.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proliferative expansion of retinal progenitor cells (RPCs) is a fundamental mechanism of growth during vertebrate retinal development. Over the past couple of years, significant progress has been made in identifying genes expressed in RPCs that are essential for their proliferation, and the molecular mechanisms are beginning to be resolved. In this review, we highlight recent studies that have identified regulatory components of the RPC cell cycle machinery and implicate a set of homeobox genes as key regulators of proliferative expansion in the retina. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：63 / 74

页数：12

共 132 条

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