DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum

被引：37

作者：

Kuo, LMY

Chen, KY

Hwang, SY

Chen, JL

Liu, YY

Liaw, CC

Ye, PH

Chou, CJ

Shen, CC

Kuo, YH ^{[1
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[2] Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, Tainan, Taiwan

[3] Chinese Culture Univ, Dept Biol, Taipei, Taiwan

[4] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan

来源：

PLANTA MEDICA | 2005年 / 71卷 / 01期

关键词：

D O I：

10.1055/s-2005-837755

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Recently, we found that the MeOH extract of Penicillium oxalicum showed inhibitory activity towards DNA topoisomerase I. Subsequently, ergosterol peroxide, ergosterol, palmitoleic acid, and linoleic acid were isolated from the cultured mycelia of A oxalicum. The structural determinations were based on physical and spectral analyses. Biological evaluation revealed that ergosterol peroxide inhibited the relaxation of supercoiled DNA (pBR322) induced by DNA topoisomerase I, and also showed marginal, selective cytotoxic activity against human colon tumor cells [COLO-205 (ED50) = 8.56 mug/mL].

引用

页码：77 / 79

页数：3

共 15 条

[1]

MINOR AND TRACE STEROLS IN MARINE-INVERTEBRATES .26. ISOLATION AND STRUCTURE ELUCIDATION OF 9 NEW 5-ALPHA,8-ALPHA-EPIDIOXY STEROLS FROM 4 MARINE ORGANISMS [J].