Approaches to the stereoselective total synthesis of biologically active natural products

被引：5

作者：

Baron, A ^{[1
]}

Ball, M ^{[1
]}

Bradshaw, B ^{[1
]}

Donnelly, S ^{[1
]}

Germay, O ^{[1
]}

Oller, PC ^{[1
]}

Kumar, N ^{[1
]}

Martin, N ^{[1
]}

O'Brien, M ^{[1
]}

Omori, H ^{[1
]}

Moore, C ^{[1
]}

Thomas, EJ ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

PURE AND APPLIED CHEMISTRY | 2005年 / 77卷 / 01期

关键词：

D O I：

10.1351/pac200577010103

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Total syntheses of epothilone B and pamamycin 607, which feature reactions between functionalized allylstannanes and aldehydes to introduce a (Z)-trisubstituted double-bond and remote stereocenters stereoselectively, are discussed. Recent work concerned with carrying out this chemistry without the use of allylstannanes as starting materials and progress toward a total synthesis of bryostatins are also presented.

引用

页码：103 / 117

页数：15

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