A common polymorphism in the tumour necrosis factor-alpha gene associated with high TNF levels is not a risk factor for venous thromboembolism

被引：17

作者：

Brown, K ^{[1
]}

Luddington, R ^{[1
]}

Baglin, T ^{[1
]}

机构：

[1] Addenbrookes NHS Trust, Dept Haematol, Cambridge CB2 2QQ, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 101卷 / 03期

关键词：

thrombosis; thromboembolism; tumour necrosis factor; TNF;

D O I：

10.1046/j.1365-2141.1998.00729.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The odds ratio of homozygosity or heterozygosity for the TNF2 polymorphism in 575 patients with venous thromboembolism compared to controls was found to be 1.0 (95% CI 0.4-2.1) and 1.1 (95% CI 0.8-1.4) respectively. Comparing subgroups of patients and controls with the factor V Leiden mutation the odds ratio for the TNF2 polymorphism was 0.7 (95% CI 0.2-2.2). Despite evidence of a link between high tumour necrosis factor (TNF) levels and hypercoagulability, our results do not indicate a link between the genetic regulation of TNF production and venous thromboembolic disease.

引用

页码：480 / 482

页数：3

共 12 条

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