Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

被引：402

作者：

Parker, JA ^{[1
]}

Arango, M ^{[1
]}

Abderrahmane, S ^{[1
]}

Lambert, E ^{[1
]}

Tourette, C ^{[1
]}

Catoire, H ^{[1
]}

Néri, C ^{[1
]}

机构：

[1] INSERM, Avenir Grp, Lab Genom Biol, Ctr Paul Broca, F-75014 Paris, France

来源：

NATURE GENETICS | 2005年 / 37卷 / 04期

关键词：

D O I：

10.1038/ng1534

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 ( Forkhead). Additionally, resveratrol rescued mutant polyglutamine - specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines.

引用

页码：349 / 350

页数：2

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