Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity

被引：118

作者：

Arthur, Janelle C. ^{[2
]}

Lich, John D. ^{[2
]}

Ye, Zhengmao ^{[2
]}

Allen, Irving C. ^{[2
]}

Gris, Denis ^{[2
]}

Wilson, Justin E. ^{[2
]}

Schneider, Monika ^{[2
]}

Roney, Kelly E. ^{[2
]}

O'Connor, Brian P. ^{[2
]}

Moore, Chris B. ^{[2
]}

Morrison, Amy ^{[2
]}

Sutterwala, Fayyaz S. ^{[5
]}

Bertin, John ^{[6
]}

Koller, Beverly H. ^{[3
]}

Liu, Zhi ^{[4
]}

Ting, Jenny P-Y. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA

[5] Univ Iowa, Inflammat Program, Dept Internal Med, Iowa City, IA 52241 USA

[6] GlaxoSmithKline Inc, Pattern Recognit Receptor Discovery Performance U, Collegeville, PA 19426 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 08期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; IMMUNE-RESPONSES; T-CELLS; ACTIVATION; INNATE; INFLAMMASOME; POPULATIONS; MONARCH-1; ANTIGEN; PROTEIN;

D O I：

10.4049/jimmunol.1002227

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nucleotide-binding domain leucine-rich repeat (NLR) proteins are regulators of inflammation and immunity. Although first described 8 y ago, a physiologic role for NLRP12 has remained elusive until now. We find that murine Nlrp12, an NLR linked to atopic dermatitis and hereditary periodic fever in humans, is prominently expressed in dendritic cells (DCs) and neutrophils. Nlrp12-deficient mice exhibit attenuated inflammatory responses in two models of contact hypersensitivity that exhibit features of allergic dermatitis. This cannot be attributed to defective Ag processing/presentation, inflammasome activation, or measurable changes in other inflammatory cytokines. Rather, Nlrp12(-/-) DCs display a significantly reduced capacity to migrate to draining lymph nodes. Both DCs and neutrophils fail to respond to chemokines in vitro. These findings indicate that NLRP12 is important in maintaining neutrophils and peripheral DCs in a migration-competent state. The Journal of Immunology, 2010, 185: 4515-4519.

引用

页码：4515 / 4519

页数：5

共 24 条

[1] ASHERSON GL, 1968, IMMUNOLOGY, V15, P405
[2] Mouse bone marrow contains large numbers of functionally competent neutrophils
Boxio, R
Bossenmeyer-Pourié, C
Steinckwich, N
Dournon, C
Nüsse, O
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (04) : 604 - 611
[3] Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
Dieu, MC
Vanbervliet, B
Vicari, A
Bridon, JM
Oldham, E
Aït-Yahia, S
Brière, F
Zlotnik, A
Lebecque, S
Caux, C
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (02) : 373 - 386
[4] The intensity of neutrophil infiltration controls the number of antigen-primed CD8 T cells recruited into cutaneous antigen challenge sites
Engeman, T
Gorbachev, AV
Kish, DD
Fairchid, RL
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (05) : 941 - 949
[5] Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity
Itano, AA
McSorley, SJ
Reinhardt, RL
Ehst, BD
Ingulli, E
Rudensky, AY
Jenkins, MK
[J]. IMMUNITY, 2003, 19 (01) : 47 - 57
[6] Mutations in NALP12 cause hereditary periodic fever syndromes
Jeru, I.
Duquesnoy, P.
Fernandes-Alnemri, T.
Cochet, E.
Yu, J. W.
Lackmy-Port-Lis, M.
Grimprel, E.
Landman-Parker, J.
Hentgen, V.
Marlin, S.
McElreavey, K.
Sarkisian, T.
Grateau, G.
Alnemri, E. S.
Amselem, S.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) : 1614 - 1619
[7] A METHOD FOR THE DERIVATION AND CONTINUOUS PROPAGATION OF CLONED MURINE BONE-MARROW MACROPHAGES
JOHNSON, CR
KITZ, D
LITTLE, JR
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (03) : 319 - 332
[8] CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells
Kabashima, Kenji
Shiraishi, Noriko
Sugita, Kazunari
Mori, Tomolko
Onoue, Ayako
Kobayashi, Miwa
Sakabe, Jun-ichi
Yoshiki, Ryutaro
Tamamura, Hirokazu
Fujii, Nobutaka
Inaba, Kayo
Tokura, Yoshilki
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (04) : 1249 - 1257
[9] The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses
Kuenzel, Sven
Till, Andreas
Winkler, Michael
Haesler, Robert
Lipinski, Simone
Jung, Sascha
Groetzinger, Joachim
Fickenscher, Helmut
Schreiber, Stefan
Rosenstiel, Philip
[J]. JOURNAL OF IMMUNOLOGY, 2010, 184 (04) : 1990 - 2000
[10] Cutting edge:: Monarch-1 suppresses non-canonical NF-κB activation and p52-dependent chemokine expression in monocytes
Lich, John D.
Williams, Kristi L.
Moore, Chris B.
Arthur, Janelle C.
Davis, Beckley K.
Taxman, Debra J.
Ting, Jenny P-Y
[J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (03) : 1256 - 1260

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