In vivo inhibition of platelet adhesion by a cGMP-mediated mechanism in balloon catheter injured rat carotid artery

被引：8

作者：

Vemulapalli, S ^{[1
]}

Chiu, PJS ^{[1
]}

Kurowski, S ^{[1
]}

Brown, A ^{[1
]}

Hartman, BD ^{[1
]}

Leach, MW ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,RES INST,LAFAYETTE,NJ

来源：

PHARMACOLOGY | 1996年 / 52卷 / 04期

关键词：

cyclic nucleotides; platelet adhesion; sodium nitroprusside; vascular injury; zaprinast;

D O I：

10.1159/000139388

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of cyclic guanosine monophosphate (cGMP) versus cyclic adenosine monophosphate (cAMP) mediated mechanism in modulating platelet adhesion was investigated in balloon catheter injured rat carotid arteries. Vascular injury with balloon angioplasty significantly increased the adherence of platelets to the injured carotid arteries. Intravenous infusion of zaprinast (1 mg/kg/min), a cGMP phosphodiesterase inhibitor, or sodium nitroprusside (8 mu g/kg/min), a stimulator of soluble guanylate cyclase, significantly attenuated the adherence of platelets to the injured carotid arteries. In comparison, infusion of milrinone, a cAMP phosphodiesterase inhibitor, or 8-bromo-cAMP failed to affect the platelet deposition in the injured carotid arteries. Nifedipine or aspirin also failed to attenuate the adherence of platelets to the injured carotid arteries. In conclusion, agents known to elevate intracellular platelet cGMP but not cAMP appear to afford the most effective protection in vivo against the adhesion of platelets to the vessel wall without intact endothelium.

引用

页码：235 / 242

页数：8

共 28 条

[1] CHARACTERIZATION OF THE CARDIOTONIC EFFECTS OF MILRINONE, A NEW AND POTENT CARDIAC BIPYRIDINE, ON ISOLATED-TISSUES FROM SEVERAL ANIMAL SPECIES [J].