Phylogenetic analysis reveals the global migration of seasonal influenza A viruses

被引:117
作者
Nelson, Martha I.
Simonsen, Lone
Viboud, Cecile
Miller, Mark A.
Holmes, Edward C. [1 ]
机构
[1] Penn State Univ, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biol, University Pk, PA 16802 USA
[3] NIH, NIAID, Bethesda, MD 20892 USA
[4] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA
关键词
D O I
10.1371/journal.ppat.0030131
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The winter seasonality of influenza A virus in temperate climates is one of the most widely recognized, yet least understood, epidemiological patterns in infectious disease. Central to understanding what drives the seasonal emergence of this important human pathogen is determining what becomes of the virus during the non-epidemic summer months. Herein, we take a step towards elucidating the seasonal emergence of influenza virus by determining the evolutionary relationship between populations of influenza A virus sampled from opposite hemispheres. We conducted a phylogenetic analysis of 487 complete genomes of human influenza A/H3N2 viruses collected between 1999 and 2005 from Australia and New Zealand in the southern hemisphere, and a representative sub-sample of viral genome sequences from 413 isolates collected in New York state, United States, representing the northern hemisphere. We show that even in areas as relatively geographically isolated as New Zealand's South Island and Western Australia, global viral migration contributes significantly to the seasonal emergence of influenza A epidemics, and that this migration has no clear directional pattern. These observations run counter to suggestions that local epidemics are triggered by the climate-driven reactivation of influenza viruses that remain latent within hosts between seasons or transmit at low efficiency between seasons. However, a complete understanding of the seasonal movements of influenza A virus will require greatly expanded global surveillance, particularly of tropical regions where the virus circulates year-round, and during non-epidemic periods in temperate climate areas.
引用
收藏
页码:1220 / 1228
页数:9
相关论文
共 30 条
[1]   Seasonality of influenza in Brazil: A traveling wave from the Amazon to the subtropics [J].
Alonso, Wladimir J. ;
Viboud, Cecile ;
Simonsen, Lone ;
Hirano, Eduardo W. ;
Daufenbach, Luciane Z. ;
Miller, Mark A. .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 165 (12) :1434-1442
[2]   The geographical spread of influenza [J].
Bonabeau, E ;
Toubiana, L ;
Flahault, A .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1998, 265 (1413) :2421-2425
[3]   Transmission of influenza: Implications for control in health care settings [J].
Bridges, CB ;
Kuehnert, MJ ;
Hall, CB .
CLINICAL INFECTIOUS DISEASES, 2003, 37 (08) :1094-1101
[4]   Invasion and maintenance of Dengue virus type 2 and type 4 in the Americas [J].
Carrington, CVF ;
Foster, JE ;
Pybus, OG ;
Bennett, SN ;
Holmes, EC .
JOURNAL OF VIROLOGY, 2005, 79 (23) :14680-14687
[5]   Global epidemiology of influenza: Past and present [J].
Cox, NJ ;
Subbarao, K .
ANNUAL REVIEW OF MEDICINE, 2000, 51 :407-421
[6]  
Dowell SF, 2001, EMERG INFECT DIS, V7, P369
[7]   Long term trends in the evolution of H(3) HA1 human influenza type A [J].
Fitch, WM ;
Bush, RM ;
Bender, CA ;
Cox, NJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :7712-7718
[8]   Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution [J].
Ghedin, E ;
Sengamalay, NA ;
Shumway, M ;
Zaborsky, J ;
Feldblyum, T ;
Subbu, V ;
Spiro, DJ ;
Sitz, J ;
Koo, H ;
Bolotov, P ;
Dernovoy, D ;
Tatusova, T ;
Bao, YM ;
St George, K ;
Taylor, J ;
Lipman, DJ ;
Fraser, CM ;
Taubenberger, JK ;
Salzberg, SL .
NATURE, 2005, 437 (7062) :1162-1166
[9]   Assessing the impact of airline travel on the geographic spread of pandemic influenza [J].
Grais, RF ;
Ellis, JH ;
Glass, GE .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2003, 18 (11) :1065-1072
[10]   EPIZOOTIOLOGY OF AVIAN INFLUENZA - EFFECT OF SEASON ON INCIDENCE IN SENTINEL DUCKS AND DOMESTIC TURKEYS IN MINNESOTA [J].
HALVORSON, DA ;
KELLEHER, CJ ;
SENNE, DA .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1985, 49 (04) :914-919