Bile acids in drug discovery

被引:142
作者
Enhsen, A [1 ]
Kramer, W [1 ]
Wess, G [1 ]
机构
[1] Hoechst Marion Roussel Deutschland GmbH, Drug Innovat & Approval, D-65926 Frankfurt, Germany
关键词
D O I
10.1016/S1359-6446(96)10046-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent advances have provided important new information on the physiological mechanisms of bile acid transport and metabolism. Bile acids, which are essential for the digestion and absorption of lipids and lipid-soluble vitamins, are metabolic: products of cholesterol and are a major regulator of cholesterol homeostasis. Bile acids are pharmacologically interesting as potential carriers of liver-specific drugs, absorption enhancers and as new cholesterol-lowering agents. Furthermore, the tools of molecular recognition and combinatorial chemistry have been used to explore the drug discovery possibilities of bile acids. The authors explore current understanding and future prospects for bile acid research.
引用
收藏
页码:409 / 418
页数:10
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