Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets

被引：73

作者：

Akoumianakis, Ioannis ^{[1
]}

Tarun, Akansha ^{[1
]}

Antoniades, Charalambos ^{[1
]}

机构：

[1] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2017年 / 174卷 / 20期

关键词：

SMOOTH-MUSCLE-CELLS; ACTIVATED-RECEPTOR-GAMMA; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; HYDROGEN-SULFIDE; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; CONCISE GUIDE; PHYSICAL-ACTIVITY; OXIDATIVE STRESS;

D O I：

10.1111/bph.13666

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Adipose tissue (AT) is an active endocrine organ with the ability to dynamically secrete a wide range of adipocytokines. Importantly, its secretory profile is altered in various cardiovascular disease states. AT surrounding vessels, or perivascular AT (PVAT), is recognized in particular as an important local regulator of vascular function and dysfunction. Specifically, PVAT has the ability to sense vascular paracrine signals and respond by secreting a variety of vasoactive adipocytokines. Due to the crucial role of PVAT in regulating many aspects of vascular biology, it may constitute a novel therapeutic target for the prevention and treatment of vascular disease pathogenesis. Signalling pathways in PVAT, such as those using adiponectin, H2S, glucagon-like peptide 1 or pro-inflammatory cytokines, are among the potential novel pharmacological therapeutic targets of PVAT.

引用

页码：3411 / 3424

页数：14

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