First experience in the use of bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns

被引:175
作者
Rasulov, MF [1 ]
Vasil'chenkov, AV [1 ]
Onishchenko, NA [1 ]
Krasheninnikov, ME [1 ]
Kravchenko, VI [1 ]
Gorshenin, TL [1 ]
Pidtsan, RE [1 ]
Potapov, IV [1 ]
机构
[1] Inst Transplantol & Artificial Organs, Moscow, Russia
关键词
bone marrow; mesenchymal stem cells; fibroblasts; burn;
D O I
10.1007/s10517-005-0232-3
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Female patient with extensive skin burn (I-II-IIIAB skin burn, total area 40%, area of IIIB degree 30%) was treated using transplantation of allogenic fibroblast-like bone marrow mesenchymal stem cells onto the surface of deep thermal burn. The study of wound healing dynamics after transplantation of allogenic fibroblast-like mesenchymal stem cells confirmed high tempo of wound regeneration in the presence of active neoangiogenesis. Due to this, autodermoplasty of bum wounds could be carried out with good results as early as on day 4 after transplantation of fibroblast-like mesenchymal stem cells; this led to more rapid healing of donor zones and accelerated rehabilitation of the patient.
引用
收藏
页码:141 / 144
页数:4
相关论文
共 19 条
[1]   Isolation of putative progenitor endothelial cells for angiogenesis [J].
Asahara, T ;
Murohara, T ;
Sullivan, A ;
Silver, M ;
vanderZee, R ;
Li, T ;
Witzenbichler, B ;
Schatteman, G ;
Isner, JM .
SCIENCE, 1997, 275 (5302) :964-967
[2]  
ASULOV MF, 2001, MED ZH UZBEKISTANA, P87
[3]  
DEDOVIC Z, 1998, ANN BURNS FIRE DISAS, V11, P37
[4]   EFFECT OF BASIC FIBROBLAST GROWTH-FACTOR (BFGF) AND INSULIN-LIKE GROWTH-FACTORS TYPE-I (IGF-I) AND TYPE-II (IGF-II) ON ADULT HUMAN KERATINOCYTE GROWTH AND FIBRONECTIN SECRETION [J].
DELAPP, NW ;
DIECKMAN, DK .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (06) :777-780
[5]  
FEDOROV VD, 1996, ANN KHIR, P16
[6]   Stimulatory effects of cartilage-derived morphogenetic proteins 1 and 2 on osteogenic differentiation of bone marrow stromal cells [J].
Gruber, R ;
Mayer, C ;
Schulz, W ;
Graninger, W ;
Peterlik, M ;
Watzek, G ;
Luyten, FP ;
Erlacher, L .
CYTOKINE, 2000, 12 (11) :1630-1638
[7]  
Kolokolchikova E. G., 2001, B EKSP BIOL MED, V131, P107
[8]  
Majumdar MK, 2000, J CELL PHYSIOL, V185, P98
[9]  
MATCHIN EN, 1998, P 2 INT WORKSH MAY 1, P25
[10]  
PARAMONOV BA, 2000, COMBUSTIOLOGY BRINK, P164