Sex differences in uric acid and risk factors for coronary artery disease

被引：152

作者：

Tuttle, KR

Short, RA

Johnson, RJ

机构：

[1] Heart Inst Spokane, Dept Res, Spokane, WA 99204 USA

[2] Washington State Univ, Spokane, WA USA

[3] Baylor Coll Med, Dept Med, Div Nephrol, Houston, TX 77030 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 12期

关键词：

D O I：

10.1016/S0002-9149(01)01566-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In conclusion, the serum uric acid level was linearly related to CAD severity in women, which likely explains the stronger association with clinical events and mortality. No such relation was observed for men. In women, CAD was predicted by metabolic syndrome risk factors, and the association with uric acid reflects this risk factor pattern. Regardless of whether hyperuricemia is an independent risk factor, it identifies a high-risk subset of women. For men, the best predictors of CAD were advanced age and microalbuminuria.

引用

收藏

页码：1411 / 1414

页数：4

相关论文

共 13 条

[1] Serum uric acid and cardiovascular events in successfully treated hypertensive patients [J].

Alderman, MH ;

Cohen, H ;

Madhavan, S ;

Kivlighn, S .

HYPERTENSION, 1999, 34 (01) :144-150

[2]

BENGTSSON C, 1988, ACTA MED SCAND, V224, P549

[3] Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study [J].

Culleton, BF ;

Larson, MG ;

Kannel, WB ;

Levy, D .

ANNALS OF INTERNAL MEDICINE, 1999, 131 (01) :7-+

[4] Sevum uric acid and cardiovascular mortality - The NHANES I epidemiologic follow-up study, 1971-1992 [J].

Fang, J ;

Alderman, MH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (18) :2404-2410

[5] RELATION OF SERUM URIC-ACID TO MORTALITY AND ISCHEMIC-HEART-DISEASE - THE NHANES-I EPIDEMIOLOGIC FOLLOW-UP-STUDY [J].

FREEDMAN, DS ;

WILLIAMSON, DF ;

GUNTER, EW ;

BYERS, T .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1995, 141 (07) :637-644

[6] MICROALBUMINURIA - ASSOCIATIONS WITH HEIGHT AND SEX IN NONDIABETIC SUBJECTS [J].

GOULD, MM ;

MOHAMEDALI, V ;

GOUBET, SA ;

YUDKIN, JS ;

HAINES, AP .

BMJ-BRITISH MEDICAL JOURNAL, 1993, 306 (6872) :240-242

[7] Effects of estrogen replacement on the progression of coronary-artery atherosclerosis [J].

Herrington, DM ;

Reboussin, DM ;

Brosnihan, KB ;

Sharp, PC ;

Shumaker, SA ;

Snyder, TE ;

Furberg, CD ;

Kowalchuk, GJ ;

Stuckey, TD ;

Rogers, WJ ;

Givens, DH ;

Waters, D .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (08) :522-529

[8]

HIYAMUTA K, 1990, JPN CIRC J, V34, P442

[9] Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women [J].

Hulley, S ;

Grady, D ;

Bush, T ;

Furberg, C ;

Herrington, D ;

Riggs, B ;

Vittinghoff, E .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (07) :605-613

[10] Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? [J].

Nieto, FJ ;

Iribarren, C ;

Gross, MD ;

Comstock, GW ;

Cutler, RG .

ATHEROSCLEROSIS, 2000, 148 (01) :131-139