Effect of aluminum on superoxide dismutase activity in the adult rat brain

被引：17

作者：

Atienzar, F

Desor, D

Burnel, D

Keller, JM

Lehr, P

Vasseur, P

机构：

[1] Univ Plymouth, Plymouth Environm Res Ctr, Plymouth PL4 8AA, Devon, England

[2] Univ Nancy 1, Fac Sci, Lab Biol & Physiol Comportement, CNRS,URA 1293, F-54500 Vandoeuvre Les Nancy, France

[3] Univ Nancy 1, Serv Chim Gen Appliquee Med, F-54500 Vandoeuvre Les Nancy, France

[4] Univ Nancy 1, Fac Sci, Lab Biol Cellulaire Dev, F-54500 Vandoeuvre Les Nancy, France

[5] Univ Metz, Ctr Environm Sci, F-57000 Metz, France

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 1998年 / 65卷 / 01期

关键词：

aluminum chloride; rat; cortex; SOD;

D O I：

10.1007/BF02784111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Male rats were treated daily with an intraperitoneal injection of 15 mg aluminum (Al chloride)/kg body weight for 17 d, in order to study the effects on superoxide dismutase (SOD) activities in the brain (cortex). No significant difference between control and treated animals was registered in the Cu/Zn and Mn SOD activities in the gray matter of the cortex. High Al levels were found in the plasma, the spleen, and the Liver of the treated animals in comparison to the controls, but not in the cortex homogenates (gray matter). In addition, Al induced a significant decrease in food ingestion and weight gain.

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收藏

页码：19 / 30

页数：12

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