Successful prevention of hematological relapse for a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic bone marrow transplantation by donor leukocyte infusion

被引：26

作者：

Yazaki, M

Andoh, M

Ito, T

Ohno, T

Wada, Y

机构：

[1] Department of Pediatrics, Nagoya City University, Medical School, Nagoya

[2] Department of Pediatrics, Nagoya City Univ. Medical School, Nagoya, 467, 1-Kawasumi, Mizuho-ku, Mizuho-cho

来源：

BONE MARROW TRANSPLANTATION | 1997年 / 19卷 / 04期

关键词：

acute lymphoblastic leukemia; bone marrow transplantation; donor leukocyte infusion; Philadelphia chromosome; reverse transcriptase-polymerase chain reaction;

D O I：

10.1038/sj.bmt.1700663

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Donor leukocyte infusion (DLI) was carried out on a 12-year-old girl with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) who received allogeneic bone marrow transplantation from an HLA-identical sibling. This is the first report of DLI use before the onset of hematological relapse monitored by the results of RT-PCR. This patient has been in CR for 11 months after BMT, suggesting this alternative treatment is promising for Ph(+) ALL with positive reverse transcriptase-polymerase chain reaction (RT-PCR) following BMT.

引用

页码：393 / 394

页数：2

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