Weighting schemes in pooled linkage analysis

被引：14

作者：

Loesgen, S

Dempfle, A

Golla, A

Bickeböller, H

机构：

[1] GSF, Natl Res Ctr Environm & Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany

[2] Tech Univ Munich, Inst Med Stat & Epidemiol, D-8000 Munich, Germany

来源：

GENETIC EPIDEMIOLOGY | 2001年 / 21卷

关键词：

genome scan; linkage analysis; pooled analysis; weights;

D O I：

10.1002/gepi.2001.21.s1.s142

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify susceptibility gene regions for complex diseases a combined linkage analysis of several genome scans might give additional insights to individual studies. In this article we consider different weighting schemes to combine the score statistics of individual studies to an overall statistic within multipoint nonparametric linkage analysis by GENEHUNTER/ALLEGRO. With the Genetic Analysis Workshop (GAW) 12 asthma data sets the weights are dominated by the large differences in the relevant sample sizes. (C) 2001 Wiley-Liss, Inc.

引用

页码：S142 / S147

页数：6

共 4 条

[1] Allegro, a new computer program for multipoint linkage analysis [J].