A snapshot of Nature's favorite pump

被引：23

作者：

Thomas, PJ ^{[1
]}

Hunt, JF

机构：

[1] Univ Texas, SW Med Ctr, Dept Physiol, Dallas, TX 75390 USA

[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 11期

关键词：

D O I：

10.1038/nsb1101-920

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 4.5 Angstrom map of the MsbA protein, a putative lipid A transporter from Escherichia coli, provides the first detailed structural model for the transmembrane domain and cytoplasmic 'loops' of an ABC transporter and the geometric relationship of these regions to the ATP-binding cassette motor domain. Based on this structure, specific hypotheses for the mechanics of the pump can now be formulated and tested.

引用

页码：920 / 923

页数：4

共 22 条

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