Retrotransposition and genomic imprinting

被引：25

作者：

Cowley, Michael ^{[1
]}

Oakey, Rebecca J. ^{[1
]}

机构：

[1] Kings Coll London, Dept Med & Mol Genet, Guys Hosp, London SE1 9RT, England

来源：

BRIEFINGS IN FUNCTIONAL GENOMICS | 2010年 / 9卷 / 04期

基金：

英国惠康基金;

关键词：

retrotransposition; retrogenes; genomic imprinting; epigenetics; GS-ALPHA GENE; GNAS CLUSTER; MOUSE; MICE; METHYLATION; CHROMOSOME; TRANSCRIPTION; EXPRESSION; SPERMATOGENESIS; IDENTIFICATION;

D O I：

10.1093/bfgp/elq015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Studies of large imprinted clusters, such as the Gnas locus, have revealed much about the significance of DNA methylation, transcription and other factors in the establishment and maintenance of imprinted gene expression. However, the complexity of such loci can make manipulating them and interpreting the results challenging. We review here a distinct class of imprinted genes, which have arisen by retrotransposition, and which have the potential to be used as models for the dissection of the fundamental features and mechanisms required for imprinting. They are also of interest in their own right, generating diversity in the transcriptome and providing raw material upon which selection can act.

引用

页码：340 / 346

页数：7

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