Selecting B cells and plasma cells to memory

被引：33

作者：

Dörner, T

Radbruch, A

机构：

[1] Univ Hosp Berlin, D-10098 Berlin, Germany

[2] Deutsches Rheumaforschungszentrum Berlin, D-10098 Berlin, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 04期

关键词：

D O I：

10.1084/jem.20050218

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humoral immunity appears to be based on immunological memory provided by memory plasma cells, which secrete protective antibodies, and memory B cells, which react to antigen challenge by differentiating into plasma cells. How these differentiation pathways relate to each other, how cells are selected into these memory populations, and how these populations are maintained remains enigmatic.

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页码：497 / 499

页数：3

相关论文

共 10 条

[1]

[Anonymous], 1890, DEUT MED WOCHENSCHR

[2] Antigen-capturing cells can masquerade as memory B cells [J].

Bell, J ;

Gray, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (10) :1233-1244

[3] Maintenance of serological memory by polyclonal activation of human memory B cells [J].

Bernasconi, NL ;

Traggiai, E ;

Lanzavecchia, A .

SCIENCE, 2002, 298 (5601) :2199-2202

[4] Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization [J].

Blink, EJ ;

Light, A ;

Kallies, A ;

Nutt, SL ;

Hodgkin, PD ;

Tarlinton, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (04) :545-554

[5] Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response [J].

Hauser, AE ;

Debes, GF ;

Arce, S ;

Cassese, G ;

Hamann, A ;

Radbruch, A ;

Manz, RA .

JOURNAL OF IMMUNOLOGY, 2002, 169 (03) :1277-1282

[6] Survival of long-lived plasma cells is independent of antigen [J].

Manz, RA ;

Löhning, M ;

Cassese, G ;

Thiel, A ;

Radbruch, A .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (11) :1703-1711

[7] Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response [J].

Odendahl, M ;

Mei, H ;

Hoyer, BF ;

Jacobi, AM ;

Hansen, A ;

Muehlinghaus, G ;

Berek, C ;

Hiepe, F ;

Manz, R ;

Radbruch, A ;

Dörner, T .

BLOOD, 2005, 105 (04) :1614-1621

[8] Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire [J].

Weller, S ;

Braun, MC ;

Tan, BK ;

Rosenwald, A ;

Cordier, C ;

Conley, ME ;

Plebani, A ;

Kumararatne, DS ;

Bonnet, D ;

Tournilhac, O ;

Tchernia, G ;

Steiniger, B ;

Staudt, LM ;

Casanova, JL ;

Reynaud, CA ;

Weill, JC .

BLOOD, 2004, 104 (12) :3647-3654

[9] Evolution of autoantibody responses via somatic hypermutation outside of germinal centers [J].

William, J ;

Euler, C ;

Christensen, S ;

Shlomchik, MJ .

SCIENCE, 2002, 297 (5589) :2066-2070

[10] On differences between immunity and immunological memory - Opinion [J].

Zinkernagel, RM .

CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (04) :523-536