WildCARDs: Inflammatory caspases directly detect LPS

被引：12

作者：

Hagar, Jon Alan ^{[1
,2
]}

Aachoui, Youssef ^{[1
,2
]}

Miao, Edward Axel ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

CELL RESEARCH | 2015年 / 25卷 / 02期

关键词：

INTRACELLULAR LPS; CYTOPLASMIC LPS; ACTIVATION; PROTECTS;

D O I：

10.1038/cr.2014.128

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Inflammasomes are sensors that serve as activation platforms for caspase-1-a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death. © 2015 IBCB, SIBS, CAS.

引用

页码：149 / 150

页数：2

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