1H-NMR study of the inclusion processes for α- and γ-cyclodextrin with fenbufen

被引：16

作者：

Bratu, I

Gavira-Vallejo, JM

Hernanz, A

机构：

[1] Univ Nacl Educ Distancia, Dept Ciencias & Tecn Fisicoquim, E-28040 Madrid, Spain

[2] Natl R&D Inst Isotop & Mol Technol, R-400293 Cluj Napoca, Romania

来源：

BIOPOLYMERS | 2005年 / 77卷 / 06期

关键词：

alpha-cyclodextrin; gamma-cyclodextrin; inclusion complexes; anti-inflammatory drugs; fenbufen; H-1-NMR; stoichiometry; stability constant; molecular modeling;

D O I：

10.1002/bip.20245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

H-1-NMR spectra of aqueous solutions of fenbufen and two cyclodextrins (alpha- or gamma-cyclodextrin, respectively) mixtures confirm the formation of an inclusion complex if gamma-cyclodextrin is used, whereas in the case of a-cyclodextrin no inclusion complex was obtained. The stoichiometry of the fenbufen/gamma-cyclodextrin complex is of the [2: 1] type. The geometry of this supramolecular architecture was established through MM+ molecular mechanics calculations. (c) 2005 Wiley Periodicals, Inc.

引用

页码：361 / 367

页数：7

共 17 条

[1]

BOGDAN M, 2000, STUD U BABES BOLYAI, P115

[2]

Inclusion complex of fenbufen with β-cyclodextrin [J].