Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning

被引:186
作者
Donnison, M [1 ]
Beaton, A [1 ]
Davey, HW [1 ]
Broadhurst, R [1 ]
L'Huillier, P [1 ]
Pfeffer, PL [1 ]
机构
[1] Agres Crown Res Inst, Hamilton 2001, New Zealand
来源
DEVELOPMENT | 2005年 / 132卷 / 10期
关键词
Elf5; extraembryonic ectoderm; trophoblast stem cells; AVE; mesoderm;
D O I
10.1242/dev.01819
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The extraembryonic ectoderm (ExE) is essential for mammalian placental formation and survival of the embryo in utero. We have obtained a mouse model lacking the ExE, by targeted deletion of the transcription factor Elf5. Although Elf5 mutant embryos implant and form an ectoplacental cone, no trophoblast stem (TS) cells can be derived, indicating that the absence of ExE is a result of the lack of TS cell maintenance. Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development.
引用
收藏
页码:2299 / 2308
页数:10
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