Low Tc SQUID measurement system for magnetic relaxation immunoassays in unshielded environment

被引：20

作者：

Haller, A ^{[1
]}

Matz, H

Hartwig, S

Kerberger, T

Atzpadin, H

Trahms, L

机构：

[1] Phys Tech Bundesanstalt, Berlin, Germany

[2] Inst Diagnostikforsch, Berlin, Germany

来源：

IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1109/77.919606

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A novel technique for detecting immunochemical reactions based on a SQUID measurement system has recently been demonstrated. The reaction partners are labeled by magnetic nanoparticles which, after an immunochemical reaction, display changes of their magnetic relaxation behaviour due to a reduction of their mobility. We have developed a SQUID system dedicated to magnetic relaxation immunoassays (MARIAs) operating in unshielded environment. The system consists of 6 SQUID magnetometers electronically combined to a second-order gradiometer. The gradiometer is formed by electronic subtraction of FLL output signals or by the Three SQUID Gradiometer approach. By evaluating the amplitude of relaxation signals (average of 4 magnetization cycles) a minimum amount of (selected) Fe2O3-particles corresponding to 600 pmol Fe was detected demonstrating the potential of the measurement system for biochemical laboratory diagnostics.

引用

页码：1371 / 1374

页数：4

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