Human papillomavirus DNA detection in women with primary abnormal cytology of the cervix: prevalence and distribution of HPV genotypes

被引:24
作者
Beerens, E
Van Renterghem, L
Praet, M
Sturtewagen, Y
Weyers, S
Temmerman, M
Depypere, H
Claeys, P
Cuvelier, CA
机构
[1] Univ Ghent, Acad Dept Pathol, B-9000 Ghent, Belgium
[2] Ghent Univ Hosp, Lab Bacteriol & Virol, B-9000 Ghent, Belgium
[3] Ghent Univ Hosp, Int Ctr Reprod Hlth, B-9000 Ghent, Belgium
[4] Ghent Univ Hosp, Dept Gynecol, B-9000 Ghent, Belgium
关键词
HPV DNA; genotypes; primary abnormal cervical cytology;
D O I
10.1111/j.1365-2303.2005.00266.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Objective: In this study, we focus on the prevalence and occurrence of different anogenital human papillomavirus (HPV) genotypes in a first abnormal cervical screening test, and correlate HPV genotyping with the cytological diagnosis on thin-layer liquid-based preparations in routine gynaecological screening. Methods: Out of 780 abnormal smears, 513 tested positive for HPV. All 25 different HPV types were identified by Line Probe Assay. Results: The prevalence of high-risk HPV types increased from 72% in atypical squamous cell of undetermined significance to 94.5% in high-grade intra-epithelial lesion (HSIL). Co-infection with multiple HPV types was predominantly found in HSIL (35.8%). In the HSIL group the most common HPV types were 16, 52, 51 and 31; type 18 was rarely present. Conclusion: The role of types 31, 51 and 52 should be considered in future studies on vaccine development.
引用
收藏
页码:199 / 205
页数:7
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