CD4+ memory T cell survival

被引：39

作者：

Taylor, Justin J.

Jenkins, Marc K. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 03期

关键词：

IN-VIVO; PRECURSOR FREQUENCY; GENERATION; EFFECTOR; NAIVE; DIFFERENTIATION; EXPRESSION; INFECTION; IMMUNITY; ANTIGEN;

D O I：

10.1016/j.coi.2011.03.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Memory CD4(+) T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naive precursors. How memory CD4(+) T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this process. Here we review the factors that allow some effector CD4(+) T cells to survive the contraction phase of the primary response and become memory cells, and consider whether parallels can be drawn between T and B cells.

引用

收藏

页码：319 / 323

页数：5

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