What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports

被引：29

作者：

Frank, S

Kieburtz, K

Holloway, R

Kim, SYH

机构：

[1] Univ Michigan, Ann Arbor, MI 48109 USA

[2] Boston Univ, Boston, MA 02215 USA

[3] Univ Rochester, Rochester, NY USA

来源：

NEUROLOGY | 2005年 / 65卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000171957.90640.b5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects receiving the procedure was small. Harm occurred more frequently in subjects randomized to the experimental intervention.

引用

收藏

页码：1101 / 1103

页数：3

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