Geometric scaling effects in electrical field flow fractionation. 1. Theoretical analysis

This work outlines the fundamental scaling laws associated with electrical held now fractionation: channels. Although general FFF theory indicates few advantages from miniaturization, EFFF theory indicates clear advantages to miniaturization of the EFFF channel. Retention,plate heights; resolution, equilibration times, and time constants are examined. The outlined theory predicts scaling advantages in each of these areas after miniaturization. Potential applications, such as the use of these systems for sample preparation in microscale total analysis systems, and improvements associated with these theoretical predictions are also discussed.