Synaptic density in the inner molecular layer of the hippocampal dentate gyrus in Alzheimer disease

被引:77
作者
Scheff, SW [1 ]
Price, DA [1 ]
机构
[1] Univ Kentucky, Sanders Brown Ctr Aging 311, Lexington, KY 40536 USA
关键词
Alzheimer disease; dementia; hippocampus; limbic system; synapses;
D O I
10.1097/00005072-199812000-00006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We examined the inner molecular layer (IML) of the hippocampal dentate gyrus for possible changes in synaptic density. Material was obtained from 9 individuals with Alzheimer disease (AD) and compared to samples obtained from 10 age-matched, postmortem-matched neurologically normal controls, employing standard ultrastructural techniques. Statistical analyses demonstrated a significant decline in synaptic numbers between controls and AD subjects. This decline was accompanied by a significant increase in apposition length and resulted in a significant correlation with the synaptic density. As the number of synapses declined, the apposition length increased. Assessment was also made of the granule cells density and the analyses showed a significant decline in the synapse to granule cell ratio in the AD group. This decline in the density of synaptic contacts in the IML reflects a more widespread decline in plasticity in AD and may be related to the memory problems associated with the disease.
引用
收藏
页码:1146 / 1153
页数:8
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