Neuronal death versus synaptic pathology in Alzheimer's disease

被引：24

作者：

Bertoni-Freddari, C

Fattoretti, P

Solazzi, M

Giorgetti, B

Di Stefano, G

Casolia, T

Meier-Ruge, W

机构：

[1] INRCA, Dept Res, Neurobiol Aging Lab, I-60121 Ancona, Italy

[2] Univ Basel, Sch Med, Inst Pathol, CH-4002 Basel, Switzerland

来源：

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷

关键词：

Alzheimer's disease; apoptosis; neuronal death; neuron density; synaptic density; synapse-to-neuron ratio; synaptic plasticity; hippocampus; cerebellum;

D O I：

10.1196/annals.1299.116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and cerebellum of adult, old, and demented (Alzheimer's disease) patients. Our findings support the notion that synaptic loss represents per se a prominent and early damage affecting zones of the central nervous system reported to show a different vulnerability to age- and pathology-related changes.

引用

页码：635 / 638

页数：4

共 5 条

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BALL MJ, 1988, INTERDISCIP TOP GERO, V25, P16

[2] Morphometry of E-PTA stained synapses at the periphery of pathological lesions [J].