Novel efficient synthesis of 1-azabicyclo[1.1.0]butane and its application to the synthesis of 1-(1,3-thiazolin-2-yl)azetidine-3-thiol useful for the pendant moiety of an oral 1β-methylcarbapenem antibiotic L-084

被引：48

作者：

Hayashi, K

Sato, C

Hiki, S

Kumagai, H

Tamai, S

Abe, T

Nagao, Y

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Wyeth Lederle Japan Ltd, Med Res Labs, Kashiwa, Chiba 3538511, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 19期

关键词：

aza compound; azetidines; cyclization; thiazolines;

D O I：

10.1016/S0040-4039(99)00603-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Azabicyclo[1.1.0]butane 2 was successfully synthesized by treatment of 2,3-dibromopropylamine hydrobromide 4 with organolithium compounds and was readily converted to 1-(1,3-thiazolin-2-yl)azetidine-3-thiol hydrochloride 1 and versatile azetidine derivatives 9 and 10. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3761 / 3764

页数：4

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