Genetics of hypertension: The adducin paradigm

被引：18

作者：

Bianchi, G

Tripodi, G

机构：

[1] Univ Vita & Salute, Osped San Raffaele, Div Nefrol Dialisi & Ipertens, Chair Nephrol, I-20132 Milan, Italy

[2] Univ Vita & Salute, Osped San Raffaele, Div Nefrol Dialisi & Ipertens, Sch Nephrol, I-20132 Milan, Italy

来源：

NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS | 2003年 / 986卷

关键词：

adducin; genetics; hypertension; Na-K pump; endocytosis; tubular renal reabsorption;

D O I：

10.1111/j.1749-6632.2003.tb07280.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na-K pump; and (4) future directions.

引用

页码：660 / 668

页数：9

共 54 条

[1] RENAL MICROPUNCTURE STUDY OF NORMOTENSIVE AND MILAN HYPERTENSIVE RATS BEFORE AND AFTER DEVELOPMENT OF HYPERTENSION
BAER, PG
BIANCHI, G
[J]. KIDNEY INTERNATIONAL, 1978, 13 (06) : 452 - 466
[2] Carotid and femoral intima-media thickness in relation to three candidate genes in a Caucasian population
Balkestein, EJ
Wang, JG
Struijker-Boudier, HAJ
Barlassina, C
Bianchi, G
Birkenhäger, WH
Brand, E
Den Hond, E
Fagard, R
Herrmann, SM
Van Bortel, LM
Staessen, JA
[J]. JOURNAL OF HYPERTENSION, 2002, 20 (08) : 1551 - 1561
[3] Carotid and femoral artery stiffness in relation to three candidate genes in a white population
Balkestein, EJ
Staessen, JA
Wang, JG
van der Heijden-Spek, JJ
Van Bortel, LM
Barlassina, C
Bianchi, G
Brand, E
Herrmann, SM
Struijker-Boudier, HA
[J]. HYPERTENSION, 2001, 38 (05) : 1190 - 1197
[4] Synergistic effect of α-adducin and ACE genes causes blood pressure changes with body sodium and volume expansion
Barlassina, C
Schork, NJ
Manunta, P
Citterio, L
Sciarrone, M
Lanella, G
Bianchi, G
Cusi, D
[J]. KIDNEY INTERNATIONAL, 2000, 57 (03) : 1083 - 1090
[5] SPECTRIN-BASED MEMBRANE SKELETON - A MULTIPOTENTIAL ADAPTER BETWEEN PLASMA-MEMBRANE AND CYTOPLASM
BENNETT, V
[J]. PHYSIOLOGICAL REVIEWS, 1990, 70 (04) : 1029 - 1065
[6] RED BLOOD-CELL ABNORMALITIES AND SPONTANEOUS HYPERTENSION IN THE RAT - A GENETICALLY-DETERMINED LINK
BIANCHI, G
FERRARI, P
TRIZIO, D
FERRANDI, M
TORIELLI, L
BARBER, BR
POLLI, E
[J]. HYPERTENSION, 1985, 7 (03) : 319 - 325
[7] CHANGES IN RENIN, WATER-BALANCE, AND SODIUM BALANCE DURING DEVELOPMENT OF HIGH BLOOD-PRESSURE IN GENETICALLY HYPERTENSIVE RATS
BIANCHI, G
BAER, PG
FOX, U
DUZZI, L
PAGETTI, D
GIOVANNETTI, A
[J]. CIRCULATION RESEARCH, 1975, 36 (06) : 153 - 161
[8] EFFECT IN CONSCIOUS DOG OF CONSTRICTION OF RENAL ARTERY TO A SOLE REMAINING KIDNEY ON HAEMODYNAMICS, SODIUM BALANCE, BODY FLUID VOLUMES, PLASMA RENIN CONCENTRATION AND PRESSOR RESPONSIVENESS TO ANGIOTENSIN
BIANCHI, G
TENCONI, LT
LUCCA, R
[J]. CLINICAL SCIENCE, 1970, 38 (06) : 741 - +
[9] Association and linkage analysis of α-adducin polymorphism:: Is the glass half full or half empty?
Bianchi, G
Cusi, D
[J]. AMERICAN JOURNAL OF HYPERTENSION, 2000, 13 (06) : 739 - 743
[10] RENAL DYSFUNCTION AS A POSSIBLE CAUSE OF ESSENTIAL-HYPERTENSION IN PREDISPOSED SUBJECTS
BIANCHI, G
CUSI, D
BARLASSINA, C
LUPI, GP
FERRARI, P
PICOTTI, GB
GATTI, M
POLLI, E
[J]. KIDNEY INTERNATIONAL, 1983, 23 (06) : 870 - 875

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