Common variants in WFS1 confer risk of type 2 diabetes

被引：273

作者：

Sandhu, Manjinder S. ^{[1
]}

Weedon, Michael N.

Fawcett, Katherine A.

Wasson, Jon

Debenham, Sally L.

Daly, Allan

Lango, Hana

Frayling, Timothy M.

Neumann, Rosalind J.

Sherva, Richard

Blech, Ilana

Pharoah, Paul D.

Palmer, Colin N. A.

Kimber, Charlotte

Tavendale, Roger

Morris, Andrew D.

McCarthy, Mark I.

Walker, Mark

Hitman, Graham

Glaser, Benjamin

Permutt, M. Alan

Hattersley, Andrew T.

Wareham, Nicholas J.

Barroso, Ines

机构：

[1] UK Med Res Council, Epidemiol Unit, Strangeways Res Lab, Cambridge CB1 8RN, England

[2] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 0SR, England

[3] Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter EX1 2LU, Devon, England

[4] Wellcome Trust Sanger Inst, Metab Dis Grp, Cambridge CB10 1SA, England

[5] Washington Univ, Sch Med, St Louis, MO 63110 USA

[6] Hadassah Hebrew Univ, Med Ctr, Endocrine & Metab Serv, IL-91120 Jerusalem, Israel

[7] Univ Cambridge, Strangeways Res Lab, Dept Oncol, Canc Res UK, Cambridge CB1 8RN, England

[8] Univ Dundee, Ninewells Hosp & Med Sch, Div Med & Therapeut, Diabet Res Grp, Dundee DD1 9SY, Scotland

[9] Univ Dundee, Ninewells Hosp & Med Sch, Populat Pharmacogenet Grp, Biomed Res Ctr, Dundee DD1 9SY, Scotland

[10] Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England

[11] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[12] Univ Newcastle, Sch Clin Med Sci, Diabet Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[13] Univ London, Queen Marys Sch Med & Dent, Ctr Diabet & Metab Med, London E1 1BB, England

来源：

NATURE GENETICS | 2007年 / 39卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/ng2067

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We studied genes involved in pancreatic beta cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

引用

页码：951 / 953

页数：3

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