ALS patients on TPPV - Totally locked-in state, neurologic findings and ethical implications

被引：81

作者：

Hayashi, H

Oppenheimer, EA

机构：

[1] Tokyo Metropolitan Neurol Hosp, Dept Neurol, Tokyo 1830042, Japan

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA

来源：

NEUROLOGY | 2003年 / 61卷 / 01期

关键词：

D O I：

10.1212/01.WNL.0000069925.02052.1F

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seventy patients with ALS using tracheostomy positive pressure ventilation (TPPV) were evaluated for impaired communication. Severely impaired communication is divided into the totally locked-in state (TLS) and the minimal communication state (MCS). TLS occurred in 8 of 70 (11.4%). In the 33 patients on TPPV for more than 5 years, TLS developed in 6 (18.2%) and MCS in 11 (33.1%). Respiratory management for ALS allows long-term survival if mechanical ventilation is used.

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页码：135 / 137

页数：3

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