The effect of short-term lipid lowering with atorvastatin on carotid artery intima media thickness in patients with peripherial vascular disease: A pilot study

被引：36

作者：

Davis, M

Atwal, AS

Nair, DR

Jagroop, IA

Seifalian, AM

Mikhailidis, DP

Hamilton, G

机构：

[1] Univ London, Royal Free & Univ Coll Med Sch, Dept Surg, London, England

[2] Univ London, Royal Free & Univ Coll Med Sch, Dept Mol Pathol & Clin Biochem, London, England

来源：

CURRENT MEDICAL RESEARCH AND OPINION | 2000年 / 16卷 / 03期

关键词：

atorvastatin; carotid artery intima media thickness; cholesterol; homocysteine; fibrinogen;

D O I：

10.1185/0300799009117026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of rapid lipid lowering (with 20 mg/day of atorvastatin) an common carotid artery intima media thickness (IMT) in patients (n = 12) with peripheral vascular disease was studied. Fasting blood samples and IMT measurements were carried out at baseline and repeated after 8 weeks' treatment. Total cholesterol decreased significantly by 27% (p < 0.0005) and low-density lipoprotein (LDL) cholesterol by 41 % (p < 0.001). The rapid reduction in lipid profiles was mirrored by a significant (p < 0.001) reduction of 15.3 % in common carotid artery IMT.

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收藏

页码：198 / 204

页数：7

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