A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11

被引：69

作者：

Parker, A

Meyer, J

Lewitzky, S

Rennich, JS

Chan, GY

Thomas, JD

Orho-Melander, M

Lehtovirta, M

Forsblom, C

Hyrkkö, A

Carlsson, M

Lindgren, C

Groop, LC

机构：

[1] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

[2] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA

[3] Univ Lund, Malmo Univ Hosp, Wallenberg Lab, Dept Endocrinol, Malmo, Sweden

来源：

DIABETES | 2001年 / 50卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.2337/diabetes.50.3.675

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed linkage to a previously unreported susceptibility locus on chromosome 18p11, This result improved with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a logarithm of odds of 3.82 (allele sharing 0.6654) at a point between markers D18S976 and D18S391 when the most obese 20% of the sample was analyzed, Several genes on chromosome 18 have been suggested as metabolic disease candidates, but none of these colocalize with our linkage result. We conclude that our results provide support for the presence of a currently uncharacterized gene on chromosome 18p, certain alleles of which confer increased susceptibility to type 2 diabetes in conjunction with obesity, We additionally observed moderate evidence for linkage to chromosome 1, near marker D1S3462; chromosome 4, near marker D4S2361; chromosome 5, near marker DS51505; and chromosome 17, near marker D17S1301.

引用

页码：675 / 680

页数：6

共 36 条

[1] Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q [J].