Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes

被引:52
作者
Christians, U
Schmidt, G
Bader, A
Lampen, A
Schottmann, R
Linck, A
Sewing, KF
机构
[1] Inst. F. Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover
[2] Inst. F. Allgemeine Pharmakologie, Medizinische Hochschule Hannover, 30625 Hannover
关键词
tacrolimus; metabolism; drug interactions; 13-O-demethyl tacrolimus; human microsomes; cytochrome P450 3A;
D O I
10.1111/j.1365-2125.1996.tb00181.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 Tacrolimus, an immunosuppressive macrolide, is metabolized by enzymes of the cytochrome P450 3A subfamily. In this study, 34 drugs were tested for their interactions with tacrolimus metabolism by human liver microsomes. 2 Fifteen drugs which inhibit the in vitro metabolism of tacrolimus were identified: bromocriptine, corticosterone, dexamethasone, ergotamine, erythromycin, ethinyloestradiol, josamycin, ketoconazole, miconazole, midazolam, nifedipine, omeprazole, tamoxifen, troleandomycin and verapamil.
引用
收藏
页码:187 / 190
页数:4
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