Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes

被引：52

作者：

Christians, U

Schmidt, G

Bader, A

Lampen, A

Schottmann, R

Linck, A

Sewing, KF

机构：

[1] Inst. F. Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover

[2] Inst. F. Allgemeine Pharmakologie, Medizinische Hochschule Hannover, 30625 Hannover

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1996年 / 41卷 / 03期

关键词：

tacrolimus; metabolism; drug interactions; 13-O-demethyl tacrolimus; human microsomes; cytochrome P450 3A;

D O I：

10.1111/j.1365-2125.1996.tb00181.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Tacrolimus, an immunosuppressive macrolide, is metabolized by enzymes of the cytochrome P450 3A subfamily. In this study, 34 drugs were tested for their interactions with tacrolimus metabolism by human liver microsomes. 2 Fifteen drugs which inhibit the in vitro metabolism of tacrolimus were identified: bromocriptine, corticosterone, dexamethasone, ergotamine, erythromycin, ethinyloestradiol, josamycin, ketoconazole, miconazole, midazolam, nifedipine, omeprazole, tamoxifen, troleandomycin and verapamil.

引用

页码：187 / 190

页数：4

共 10 条

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