Evidence for cross-reactivity between antigen derived from Trypanosoma cruzi and myelin basic protein in experimental Chagas disease

被引：12

作者：

Al-Sabbagh, A

Garcia, CAAC

Diaz-Bardales, BM

Zaccarias, C

Sakurada, JK

Santos, LMB ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Biol, Dept Microbiol & Imunol, BR-13081970 Campinas, SP, Brazil

[2] Autoimmune Inc, Lexington, MA USA

来源：

EXPERIMENTAL PARASITOLOGY | 1998年 / 89卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

myelin basic protein; Trypanosoma cruzi; autoimmunity; antigenic mimicry;

D O I：

10.1006/expr.1998.4279

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Evidence for crossreactivity between antigen derived from Trypanosoma cruzi and myelin basic protein in experimental Chagas disease. Experimental Parasitology 89, 304-311. Some autoimmune diseases are thought to arise after an infection. Infectious agents can initiate a chronic inflammatory response associated with autoimmune reactions. Chagas disease, caused by the intracellular parasite Trypanosoma cruzi, is an excellent model for autoimmune disease induced by an infection. The chronic disease is characterized by rich inflammatory infiltrate in myocardial and nervous tissues, with virtually no demonstrable parasites. We were able to demonstrate the presence of antibody to myelin basic protein (MBP) in the serum from T. cruzi chronically infected mice. Lymphocytes from mice immunized with T. cruzi-derived soluble extract antigen (TCSE) proliferate in response to MBP in vitro. Lymphocytes from animals immunized with MBP also were activated by TCSE in vitro. By studying the overlapping peptides from the MBP molecule, we were able to identify two regions responsible for the cross-reactivity. (C) 1998 Academic Press.

引用

页码：304 / 311

页数：8

共 19 条

[1] EXPERIMENTAL AUTOIMMUNE PERIPHERAL NEURITIS INDUCED IN BALB/C MICE BY MYELIN BASIC PROTEIN-SPECIFIC T-CELL CLONES [J].