PspC, a pneumococcal surface protein, binds human factor H

被引：158

作者：

Dave, S

Brooks-Walter, A

Pangburn, MK

McDaniel, LS

机构：

[1] Univ Mississippi, Med Ctr, Dept Microbiol, Jackson, MS 39216 USA

[2] Univ Mississippi, Med Ctr, Dept Surg, Jackson, MS 39216 USA

[3] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA

[4] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA

[5] Univ Texas, Hlth Sci Ctr, Dept Biochem, Tyler, TX 75708 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 05期

关键词：

D O I：

10.1128/IAI.69.5.3435-3437.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PspC was found to bind human complement factor H (PH) by Western blot analysis of D39 (pspC(+)) and an isogenic mutant TRE108 (pspC). We confirmed that PspA does not bind FH, while purified PspC binds PH very strongly, The binding of PH to exponentially growing pneumococci varied among different isolates when analyzed by fluorescence activated cell sorting analysis.

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页码：3435 / 3437

页数：3

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