Diagnostic lessons of mucosal melanoma with osteocartilaginous differentiation

被引:36
作者
Banerjee, SS
Coyne, JD
Menasce, LP
Lobo, CJ
Hirsch, PJ
机构
[1] Christie Hosp NHS Trust, Dept Pathol, Manchester M20 4BX, Lancs, England
[2] Univ S Manchester Hosp, NHS Trust, Dept Pathol, Manchester M20 8LR, Lancs, England
[3] Univ S Manchester Hosp, NHS Trust, Dept Obstet & Gynaecol, Manchester M20 8LR, Lancs, England
[4] Christie Hosp NHS Trust, Dept Otolaryngol, Manchester, Lancs, England
关键词
mucosal malignant melanoma; oral and nasal cavity; osteocartilaginous differentiation; vagina;
D O I
10.1046/j.1365-2559.1998.00494.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Aims: To document the clinical, morphological and immunohistochemical features of two cases of primary mucosal melanoma with osteocartilaginous differentiation. Materials ann methods: Two cases of mucosal melanoma with cartilage and bone formation are reported, one arising in the vagina of a 79-year-old woman and one in the oral cavity of a 67-year-old man, The vaginal melanoma exhibited only cartilaginous differentiation. The oral cavity mucosal melanoma exhibited both bone and cartilage formation and was remarkable for its multifocality, long history not associated with metastases and its lengthy manifestation of dual morphologies: some of the tumours were typical in situ/invasive melanotic melanomas whilst the others were composed of amelanotic spindle and epithelioid cells with osteocartilaginous tissue, One of the lesions exhibited in situ and invasive melanoma with transition to an osteogenic tumour in places, The patient also developed nonosteogenic malignant melanomas in the nasal cavity and nasopharynx. Conclusions: Malignant melanomas showing foci of osteocartilaginous differentiation are extremely rare with only 18 cases reported. Primary mucosal malignant melanomas of vagina and oral cavity showing osteocartilaginous differentiation have not previously been documented, Primary vaginal melanoma with cartilaginous differentiation must be distinguished from primary malignant mixed Mullerian tumour whilst malignant change in a pleomorphic adenoma, sarcomatoid carcinoma, osteogenic sarcoma and mesenchymal chondrosarcoma are included in the differential diagnosis of primary oral mucosal melanomas with osteocartilaginous differentiation. In this context, immunohistochemistry using antibodies to cytokeratin, S100 protein and MIC2 is of value.
引用
收藏
页码:255 / 260
页数:6
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