Tumor expression of Fas ligand (CD95L) and the consequences

被引：113

作者：

Walker, PR

Saas, P

Dietrich, PY

机构：

[1] Univ Hosp Geneva, Div Tumor Immunol, Div Oncol, CH-1211 Geneva 14, Switzerland

[2] ETS Franche Comte, Lab Therapeut Immunomol, F-25020 Besancon, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80225-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand. The final in vivo outcome of CD95 ligand expression will depend upon a complex balance of interactions relevant for each tumor in its particular microenvironment.

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页码：564 / 572

页数：9

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