Biological interaction between transition metals (Ag, Cd and Hg), selenide/sulfide and selenoprotein P

被引:201
作者
Sasakura, C [1 ]
Suzuki, KT [1 ]
机构
[1] Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
关键词
selenium; mercury; silver; cadmium; selenoprotein P;
D O I
10.1016/S0162-0134(98)10048-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The interaction between transition metals (Ag+, Cd2+ and Hg2+) and selenium (Se) in the bloodstream was studied in vitro by means of the HPLC - inductively coupled argon plasma-mass spectrometry (ICP MS) method. Transition metal ions and selenide (produced in vitro from selenite in the presence of glutathione) or sulfide (Na2S) formed a (metal-Se/S) complex, which then bound to a plasma protein, selenoprotein P (Sel P), to form a ternary complex, (metal-Se/S)-Sel P. The molar ratios of metals to Se were 1:1 for Hg/Se and Cd/Se, but either 1:1 or 2:1 for Ag/Se, depending on the ratio of their doses. The results indicate that the interaction between transition metals and Se occurs through the general mechanism, i.e., transition metal ions and selenide form the unit complex (metal-Se)(n), and then the complex binds to selenoprotein P to form the ternary complex {(metal-Se)(n)}(m) - seleno-protein P in the bloodstream. (C) 1998 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:159 / 162
页数:4
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