Jun expression is found in neurons located in the vicinity of subacute plaques in patients with multiple sclerosis

被引:24
作者
Martin, G
Segui, J
DiazVilloslada, P
Montalban, X
Planas, AM
Ferrer, I
机构
[1] UNIV BARCELONA,HOSP PRINCEPS ESPANYA,SERV ANAT PATOL,UNITAT NEUROPATOL,E-08907 LHOSPITALET LLOBR,BARCELONA,SPAIN
[2] HOSP GEN VALLE HEBRON,SERV NEUROL,UNITAT RECERCA NEUROL,BARCELONA,SPAIN
[3] CSIC,CIC,DEPT FARMACOL & TOXICOL,BARCELONA,SPAIN
关键词
Jun; Fos; transcription factors; demyelination; axonal damage; multiple sclerosis; regeneration;
D O I
10.1016/0304-3940(96)12776-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The expression of members of the Fos and Jun families is examined by immunohistochemistry in the brains of two patients with multiple sclerosis (MS). Strong c-Jun immunoreactivity is observed in the cytoplasm of neurons located in the vicinity of subacute plaques, but not in neurons of brain compartments not compromised by MS and in the neighborhood of chronic plaques. Strong c-Jun immunoreactivity also contrast with weak c-Jun immunoreactivity of corresponding neurons in control brains. In addition, punctate Jun D immunoreactivity is observed in the neuropil of the same areas that express c-Jun. No immunoreaction is found to c-Fos, Fos-related antigens and Jun B in these areas. The present results suggest that selective Jun neuronal expression in the vicinity of subacute plaques is a consistent reaction to demyelination and axonal damage.
引用
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页码:95 / 98
页数:4
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