Common Behavioral Clusters and Subcortical Anatomy in Stroke

被引：345

作者：

Corbetta, Maurizio ^{[1
,2
,3
,5
]}

Ramsey, Lenny ^{[1
,4
]}

Callejas, Alicia ^{[1
]}

Baldassarre, Antonello ^{[1
]}

Hacker, Carl D. ^{[5
]}

Siegel, Joshua S. ^{[4
]}

Astafiev, Serguei V. ^{[1
]}

Rengachary, Jennifer ^{[1
]}

Zinn, Kristina ^{[1
]}

Lang, Catherine E. ^{[1
,6
,7
]}

Connor, Lisa Tabor ^{[1
,2
,7
]}

Fucetola, Robert ^{[1
]}

Strube, Michael ^{[8
]}

Carter, Alex R. ^{[1
]}

Shulman, Gordon L. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Radiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Div Biomed Sci, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Dept Bioengn, St Louis, MO 63110 USA

[6] Washington Univ, Sch Med, Dept Phys Therapy, St Louis, MO 63110 USA

[7] Washington Univ, Sch Med, Dept Occupat Therapy, St Louis, MO 63110 USA

[8] Washington Univ, Sch Med, Dept Psychol, St Louis, MO 63110 USA

来源：

NEURON | 2015年 / 85卷 / 05期

关键词：

FUNCTIONAL CONNECTIVITY; HEMISPATIAL NEGLECT; SPATIAL NEGLECT; PARIETAL CORTEX; HUMAN BRAIN; LESION; NETWORK; SCALE; ATTENTION; APHASIA;

D O I：

10.1016/j.neuron.2015.02.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

A long-held view is that stroke causes many distinct neurological syndromes due to damage of specialized cortical and subcortical centers. However, it is unknown if a syndrome-based description is helpful in characterizing behavioral deficits across a large number of patients. We studied a large prospective sample of first-time stroke patients with heterogeneous lesions at 1-2 weeks post-stroke. We measured behavior over multiple domains and lesion anatomy with structural MRI and a probabilistic atlas of white matter pathways. Multivariate methods estimated the percentage of behavioral variance explained by structural damage. A few clusters of behavioral deficits spanning multiple functions explained neurological impairment. Stroke topography was predominantly subcortical, and disconnection of white matter tracts critically contributed to behavioral deficits and their correlation. The locus of damage explained more variance for motor and language than memory or attention deficits. Our findings highlight the need for better models of white matter damage on cognition.

引用

页码：927 / 941

页数：15

共 49 条

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