Epithelial M cells: Differentiation and function

被引:340
作者
Kraehenbuhl, JP [1 ]
Neutra, MR
机构
[1] Univ Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland
[2] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland
[3] Childrens Hosp, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
关键词
M cells; Peyer's patches; mucosal immunity; epithelium; microorganisms;
D O I
10.1146/annurev.cellbio.16.1.301
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
M cells are distinctive epithelial cells that occur only in the follicle-associated epithelia that overlie organized mucosa-associated lymphoid tissues. They are structurally and functionally specialized for transepithelial transport, delivering foreign antigens and microorganisms to organized lymphoid tissues within the mucosae of the small and large intestines, tonsils and adenoids, and airways. M cell transport is a double-edged sword: Certain pathogens exploit the features of M cells that are intended to promote uptake for the purpose of immunological sampling. Eludication of the molecular architecture of M cell apical surfaces is important for understanding the strategies that pathogens use to exploit this pathway and for utilizing M cell transport for delivery of vaccines to the mucosal immune system. This article reviews the functional and biochemical features that distinguish M cells from other intestinal cell types. In addition it synthesizes the available information on development and differentiation of organized lymphoid tissues and the specialized epithelium associated with these immune inductive sites.
引用
收藏
页码:301 / 332
页数:32
相关论文
共 166 条
[1]   Three distinctive steps in Peyer's patch formation of murine embryo [J].
Adachi, S ;
Yoshida, H ;
Kataoka, H ;
Nishikawa, S .
INTERNATIONAL IMMUNOLOGY, 1997, 9 (04) :507-514
[2]   Essential role of IL-7 receptor α in the formation of Peyer's patch anlage [J].
Adachi, S ;
Yoshida, H ;
Honda, K ;
Maki, K ;
Saijo, K ;
Ikuta, K ;
Saito, T ;
Nishikawa, S .
INTERNATIONAL IMMUNOLOGY, 1998, 10 (01) :1-6
[3]   Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice [J].
Alimzhanov, MB ;
Kuprash, DV ;
KoscoVilbois, MH ;
Luz, A ;
Turetskaya, RL ;
Tarakhovsky, A ;
Rajewsky, K ;
Nedospasov, SA ;
Pfeffer, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9302-9307
[4]   RAT INTESTINAL M CELLS CONTAIN ACIDIC ENDOSOMAL-LYSOSOMAL COMPARTMENTS AND EXPRESS CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX DETERMINANTS [J].
ALLAN, CH ;
MENDRICK, DL ;
TRIER, JS .
GASTROENTEROLOGY, 1993, 104 (03) :698-708
[5]   PROTEOLYTIC PROCESSING OF REOVIRUS IS REQUIRED FOR ADHERENCE TO INTESTINAL M-CELLS [J].
AMERONGEN, HM ;
WILSON, GAR ;
FIELDS, BN ;
NEUTRA, MR .
JOURNAL OF VIROLOGY, 1994, 68 (12) :8428-8432
[6]   A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function [J].
Anderson, DM ;
Maraskovsky, E ;
Billingsley, WL ;
Dougall, WC ;
Tometsko, ME ;
Roux, ER ;
Teepe, MC ;
DuBose, RF ;
Cosman, D ;
Galibert, L .
NATURE, 1997, 390 (6656) :175-179
[7]   ANALYSIS OF THE ROLES OF ANTILIPOPOLYSACCHARIDE AND ANTICHOLERA TOXIN IMMUNOGLOBULIN A (IGA) ANTIBODIES IN PROTECTION AGAINST VIBRIO-CHOLERAE AND CHOLERA-TOXIN BY USE OF MONOCLONAL IGA ANTIBODIES IN-VIVO [J].
APTER, FM ;
MICHETTI, P ;
WINNER, LS ;
MACK, JA ;
MEKALANOS, JJ ;
NEUTRA, MR .
INFECTION AND IMMUNITY, 1993, 61 (12) :5279-5285
[8]   Chemokines and leukocyte traffic [J].
Baggiolini, M .
NATURE, 1998, 392 (6676) :565-568
[9]  
BASS DM, 1988, LAB INVEST, V58, P226
[10]   The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches [J].
Baumler, AJ ;
Tsolis, RM ;
Heffron, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :279-283