The role of Extracellular Vesicles during CNS development

被引：49

作者：

Sangani, Nasim Bahram ^{[1
,2
]}

Gomes, Ana Rita ^{[3
,4
,5
]}

Curfs, Leopold M. G. ^{[2
]}

Reutelingsperger, Chris P. ^{[1
,2
]}

机构：

[1] Maastricht Univ, Dept Biochem, Cardiovasc Res Inst Maastricht, POB 616, NL-6200 MD Maastricht, Netherlands

[2] Maastricht Univ, GKC Rett Expertise Ctr, Med Ctr, Maastricht, Netherlands

[3] Univ Lisbon, Inst Super Tecn, Dept Bioengn, Av Rovisco Pais, P-1049001 Lisbon, Portugal

[4] Univ Lisbon, Inst Super Tecn, IBB Inst Bioengn & Biosci, Av Rovisco Pais, P-1049001 Lisbon, Portugal

[5] Univ Lisbon, Fac Med, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal

来源：

PROGRESS IN NEUROBIOLOGY | 2021年 / 205卷

关键词：

Extracellular vesicles; Exosomes; Intracellular communication; neuron; glia; CNS development; NEURAL STEM-CELL; OUTER SUBVENTRICULAR ZONE; HUMAN CEREBRAL-CORTEX; GLUTAMATE TRANSPORTERS; NEURONAL SPECIFICATION; ADULT NEUROGENESIS; PROGENITOR CELLS; RETT-SYNDROME; GAG PROTEIN; RADIAL GLIA;

D O I：

10.1016/j.pneurobio.2021.102124

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

With a diverse set of neuronal and glial cell populations, Central Nervous System (CNS) has one of the most complex structures in the body. Intercellular communication is therefore highly important to coordinate cell-tocell interactions. Besides electrical and chemical messengers, CNS cells also benefit from another communication route, what is known as extracellular vesicles, to harmonize their interactions. Extracellular Vesicles (EVs) and their subtype exosomes are membranous particles secreted by cells and contain information packaged in the form of biomolecules such as small fragments of DNA, lipids, miRNAs, mRNAs, and proteins. They are able to efficiently drive changes upon their arrival to recipient cells. EVs actively participate in all stages of CNS development by stimulating neural cell proliferation, differentiation, synaptic formation, and mediating reciprocal interactions between neurons and oligodendrocyte for myelination process. The aim of the present review is to enlighten the presence and contribution of EVs at each CNS developmental milestone.

引用

页数：14

共 207 条

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