Themes in ion pump regulation

被引：10

作者：

Cornelius, F ^{[1
]}

Mahmmoud, YA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Biophys, DK-8000 Aarhus C, Denmark

来源：

NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS | 2003年 / 986卷

关键词：

FXYD proteins; PLMS; protein kinase; multisite phosphorylation; leucine zipper;

D O I：

10.1111/j.1749-6632.2003.tb07256.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Na,K-ATPase is an ion pump present in the plasma membrane. It is of vital importance for cell and body homeostasis and as such is under strict hormonal control. The molecular basis for the acute regulation of Na,K-ATPase is multisite phosphorylation by protein kinases that can alter its behavior. This includes direct effects on the Na,K-ATPase activity, regulation by membrane trafficking, and even dynamic regulation of interaction with regulatory proteins. In shark Na,K-ATPase, the latter includes functional interaction with a small hydrophobic protein of the FXYD protein family, phospholemman-like protein from shark, PLMS. This article summarizes our recent work on the mechanisms involved in the acute regulation of the Na,K-ATPase studied using a plasma membrane preparation from shark salt glands as an epithelial transport model.

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收藏

页码：579 / 586

页数：8

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